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From the country’s pop music whose artists have reached global stardom to the rising fame and popularity of the country’s hip hop scene, South Korea is arguably the music capital of Asia. Similar to many Asian countries, South Korea has a powerful history of cultures and traditions, but no other country in Asia has as great of a music scene as South Korea. Those are just a handful of Korean hip hop artists that should be considered as key contributors to hip hop’s growth in South Korea. Artists like Deux, Seo Taiji and Boys, Poppin’ Hyun Joon, Solid, who were also labeled as the originators of Korean R&B, or G-Dragon, who along with artists T.O.P and Taeyang formed Big Bang, one of the first international K-Pop acts. Outside of the legendary career of Hyun Jinyoung, various solo artists and groups also contributed to the growth of Korean rap and hip hop music. ![]() ![]() His reign in Korean music was throughout the 1990s and the early 2000s. An artist known as Hyun Jinyoung is not only known as a pioneer of Korean hip hop, but also one of the originators of K-Pop. In the early days of rap music in South Korea, the genre was often implemented with Korean pop music, sometimes called K-Hip Hop, which has also continued in today’s generation of Korean hip hop. While K-Pop is the country’s leading genre of music, there is another side of South Korea’s local music scene that consists of Korean rap artists who have over the years developed a nice sizable roster and lineup of Korean hip hop artists. ![]() Korean rappers of South Korea have created a flourishing rap scene in a somewhat small hip hop market within a country that has widely been known for the popularity of Korean pop music, often referred as K-Pop, with girl groups and boy bands. 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Scroll through the profiles to locate your specific peripheral and version.Click Control Profiles to display the list of peripheral keybindings that we provide.Click Advanced Controls Customization bottom left.For this example, select Joystick / HOTAS. Would make sense to invert the option under that stick, right No joy. For me, my stick was Joystick/HOTAS 1 but the separate throttle becomes Joystick / HOTAS 2 and has to be configured there. Set to the peripheral you want to customize keybindings in the lower right. In OPTIONS -> CONTROLS, note the button bottom right that allows you to select the device you want to modify.You can also modify and create keybinding profiles! Community players also provide exported XML files for peripherals and types of gameplay. If you want to import a keybinding profile from your collection or a community member, see Create, export, and import custom profiles. We provide profiles of keybindings out-of-the-box you can load per peripheral. Star Citizen supports multiple types of game peripherals including joysticks, rudders, mouse, keyboard, and more. pH-dependent homotypic association involves specific pairing between the A2, A3, D4 and six smaller domains between D4 and CK ( Fig. 1C). ![]() ![]() The term dimeric bouquet describes the appearance in EM of the A2, A3, and D4 domains as six flowers in a raceme, and C-terminal domains as a stem. N-linked glycans are processed, and O-linked glycans are added.Ī previously undescribed dimeric bouquet forms at pH 6.2 in the C-terminal portion of VWF (Y.-F. ProVWF dimers are then transported from the ER (pH approximately 7.4) to the Golgi (pH approximately 6.2). N-linked glycans are added in the ER, most disulphide bonds are formed, and proVWF is dimerised through formation of inter-monomer disulphide bonds in the C-terminal cystine-knot (CK) domain ( Fig. 1B). VWF glycoprotein is biosynthesised as a preproprotein the signal sequence is removed during translocation into the endoplasmic reticulum (ER) ( Fig. 1A). Multiple biological specialisations are required for the biosynthesis of the largest known soluble vertebrate protein. EM evidence for N-terminal D1-D2 homodimerisation and the helical assembly is from. EM evidence for C-terminal pH-regulated dimeric bouquet and domain shapes is from Y.-F. (B–E) Scheme for biosynthesis, helical assembly, and secretion. N and O-linked glycans are closed and open lollipops, respectively. Cysteines are vertical lines and are connected for chemically determined disulphide bonds. (A) Primary structure and domain organisation of VWF. Mutations in von Willebrand disease (VWD) both contribute to and are illuminated by understanding of VWF biology.īiosynthesis, helical assembly, and secretion of VWF concatamers. I review recent advances in our understanding of the biosynthesis, activation by elongational flow, mechanoenzymatic length regulation, and biophysics of the A1 and A2 domains of VWF. These forces activate both the haemostatic function and thrombotic pathology of VWF. The enormous length of VWF concatamers brings them into a range where the hydrodynamic forces acting on them in the circulation are highly significant, like on blood cells in the circulation, whereas such forces on other plasma proteins and cell surface receptors are negligible. ‘Multimer’ denotes both branched and unbranched polymers because the biology and physics of VWF are intertwined with the linear nature of its polymer, I prefer the more specific term ‘concatamer’ for a linear polymer. ![]() VWF multimers are organised as long linear concatamers, in which each monomer disulphide bonds tail-to-tail at its C-terminus, and head-to-head at its N-terminus, with adjacent monomers ( Fig. 1). Different domains within VWF bind clotting factor VIII, collagen, platelet glycoprotein Ib (GPIb), and integrins α IIbβ 3 and α Vβ 3 ( Fig. 1A). Von Willebrand factor (VWF) is central in haemostasis and thrombosis in the rapid flow of the arteriolar circulation. Single molecule studies on the A1-GPIb receptor-ligand bond demonstrate a specialised flex-bond that enhances resistance to the strong hydrodynamic forces experienced at sites of haemorrhage. Recent structures of A2 and single molecule measurements of A2 unfolding and cleavage by ADAMTS13 illuminate the mechanisms of VWF length regulation. Elongational forces regulate haemostasis by activating binding of the A1 domain to platelet GPIbα, and over longer time periods, regulate VWF length by unfolding of the A2 domain for cleavage by ADAMTS13. Moreover, elongational hydrodynamic forces on VWF are strongest just where needed, when bound to the vessel wall, or in elongational flow in the circulation at sites of vessel rupture or vasoconstriction in haemostasis. VWF is longest at its site of secretion, where its haemostatic function is most important. Length regulation occurs post-secretion, by hydrodynamic force-regulated unfolding of the VWF A2 domain, and its cleavage by the plasma protease ADAMTS13 (a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13). Orderly assembly and storage of ultra-long concatamers in helical tubules, without crosslinking of neighboring tubules, enables unfurling during secretion without entanglement. Specialisations include a pH-regulated dimeric bouquet formed by the C-terminal half of VWF and helical assembly guided by the N-terminal half that templates inter-dimer disulphide bridges. ![]() Structural specialisations enable von Willebrand factor (VWF) to assemble during biosynthesis into helical tubules in Weibel-Palade bodies (WPB). If you have additional questions, contact an attorney in your area. It is always best to consult your own state's regulations when it comes to audio recording rules. The moment she enters a space deemed private-such as a restroom, or a personal bedroom she may have in your home-she should expect privacy and consequently can't be legally recorded.Īudio Recording Consent Regulations By State Think of your baby's room as the aisles of your store-a nanny shouldn't expect privacy there-and therefore you are given the right to record her. Someone entering your home, however, is subject to the same expectations of privacy they might have in a department store. In your own home it's a given that you yourself have a reasonable expectation of privacy. Additionally, it is illegal to record employees' union activities due to regulations codified in the National Retail Labor Relations Act. If you’re a business owner or manager, the best rule of thumb is to always notify employees of any video recording devices in use at your place of business (audio recording is not permitted without the expressed consent of all employees, which will be discussed later in this article). That said, some employees expect a certain level of privacy in their personal workspaces, for example, making the regulations slightly more complicated. In many ways, employee monitoring is subject to the same regulations as public recording: Cameras aren't allowed in places where employees have a reasonable expectation of privacy. Many employers will use surveillance cameras, or hidden cameras, to protect and monitor their employees in addition to their customers. And, should you find out you're being filmed in that private space, the store is legally liable for that invasion of privacy. The moment you enter a changing room or a restroom, however, you are afforded a reasonable expectation of privacy. In the same way you wouldn't expect privacy walking down the street, you wouldn't expect it walking down the aisles of a department store. By entering a store you are exiting an outdoor public arena, but you're then subject to the store's public space. This same rules apply to commercial properties. Under the law as it relates to video recording, you have no reasonable expectation of privacy when you're in a public space-if you can be seen by the naked eye, it's safe to assume that you can also be seen and/or recorded by a video camera. Laws regulating video recording boil down to one key factor: Do I, as a citizen, have a reasonable expectation of privacy where I am? If the answer to that question is yes, then odds are you are not legally allowed to be recorded without your expressed permission. For example, if you're walking down the street, you may be recorded by a myriad of cameras without your knowledge: Traffic cameras, security cameras monitoring the exterior of buildings, news helicopters flying overhead, etc. Video Recording: A Reasonable Expectation of Privacy In the United States, regulations governing audio recording are drastically different from laws governing video recording-crucial differences that come down to matters of privacy and consent. ![]() While it’s possible to purchase hidden cameras with audio recording capability on the internet from disreputable dealers, you should know that by doing so, you’re risking up to a $250,000 fine and up to five years in jail. There is an exception to the law governing the sale and use of these recording devices to authorized law enforcement agents, which is explained in more detail below. The law makes it clear that it’s illegal for BrickHouse Security to sell certain types of audio recording devices-and it’s illegal for a US citizen to possess and use them to surreptitiously record the private conversations of others without their consent. “… Any person who intentionally… manufactures, assembles, possesses, or sells any electronic, mechanical, or other device, knowing or having reason to know that the design of such device renders it primarily useful for the purpose of the surreptitious interception of wire, oral, or electronic communications, and that such device or any component thereof has been or will be sent through the mail or transported in interstate or foreign commerce… shall be fined under this title or imprisoned not more than five years, or both.” This law is a federal prohibition on the sale and use of devices designed to covertly record the voices of people without their consent. The federal law that applies to audio recording is US Code Title 18, Part 1, Chapter 119, which you can read in full here. Paging through the hundreds of hidden cameras available from BrickHouse Security, you may be surprised to see this disclaimer at the bottom many pages: "Due to federal regulations, this camera does not record audio." You may ask, what federal regulations? And why? A Primer on Privacy, Consent, and US Recording Laws They are small animals and love to chew upon almost everything. Why do we think this is hedgehog rodents? It’s not your fault that you mistook a hedgehog with a rat or rodent. Hedgehogs, however, they do turn their hair into quills that they use for defensive purposes. Unlike porcupines and similar to rodents, they can eat anything without showing any mood including small insects and several other stuff. Hedgehogs share their heredity with shrews That clearly means that they are not at all related to either rodents or porcupines. They belong to the order called Erinaceomorpha. Talking about hedgehogs I should clarify to you that they are anything but not rodents. We know that mice, rats, and creatures like hamsters belong to the rodent family but anything similar to these creatures can’t be included in the rodent family. You and I may have gone through this phrase from our grandparents that any creature that tries to peek in or is seen crawling in your yard is a rodent. Mostly we follow our elders while following myths. Similarities between hedgehogs and rodents:.Dissimilarities between hedgehog and rodents:.Are Hedgehogs Rodents? 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